Showing posts with label Antibiotics. Show all posts
Showing posts with label Antibiotics. Show all posts

Monday, January 23, 2012

20 Facts to Know About Antibiotics

Antibiotics play a very foremost role of modern medicine. These medications are used to fight many infections caused by bacteria. The following facts about antibiotics will help you understand how these drugs work, their inherent side effects and the point of taking antibiotics as directed by your doctor.

Antibiotics belong to a class of drugs called Antimicrobials. Other drugs in this group include antifungals, antiprotozoals and antivirals. Antibiotics are medicines that kill bacteria. These drugs do not work on viruses. A bacterium is a living, reproducing lifeform. A virus is just a piece of Dna (or Rna). A virus injects its Dna into a living cell and has that cell reproduce more of the viral Dna. With a virus there is nothing to "kill," so antibiotics don't work on it. There are many types of antibiotics. Each works a slight differently and acts on distinct types of bacteria. Some antibiotics are efficient against only clear types of bacteria; others can effectively fight a wide range of bacteria. While the use of antibiotics did not begin in the 20th century, early folk treatment included the use of mouldy foods or soil for infections. In old Egypt, for example, infections were treated with mouldy bread. Originally noticed by a French curative student, Ernest Duchesne, in 1896, penicillin was re-discovered by bacteriologist Alexander Fleming working at St. Mary's Hospital in London in 1928. He observed that a plate culture of Staphylococcus had been contaminated by a blue-green mold and that colonies of bacteria adjacent to the mold were being dissolved. A broad spectrum antibiotic is one that can kill many distinct types of bacteria. A broad spectrum antibiotic is beneficial for treating infections that might be caused by many distinct types of bacteria such as ear infections. A narrow spectrum antibiotic is one that kills only a small collection of germs. Antibiotics must be taken for the full number of time prescribed by your doctor. Many times, patients will stop the use of an antibiotic when they begin to feel best and it seems that the illness has gone. However, even after the symptoms are gone, the bacteria may still be gift in small amounts and an infection can return if use of the antibiotic is stopped. Not completing the prescribed dose also may promote resistance. There are two major drawbacks of antibiotics: Bacterial resistance Harmful side effects Bacteria may be naturally resistant to distinct classes of antibiotics or may regain resistance from other bacteria straight through exchange of resistant genes. Antibiotics commonly are safe. The most coarse side effects of antibiotics include stomach upset, nausea, and diarrhea. An increased sensitivity to sunlight is coarse with tetracyclines (e.g. doxycycline, minocycline) and fluoroquinolones (e.g. Ciprofloxacin , ofloxacin, levofloxacin). Although most side-effects may be mild in appearance, some may be severe like allergic reactions and it may even be life-threatening allergic reactions. Should you perceive any unexpected reaction to an antibiotic you use for the first time, immediately consult with your health professional. Antibiotics can kill most of the bacteria in your body that are sensitive to them, along with "good" bacteria. By destroying the bacterial balance, they may cause stomach upsets, diarrhea, yeast infections or other problems. Any antibiotic can suppress the healthy bacteria in your colon. Regularly this qoute surfaces when the newer, more suited antibiotics are prescribed, or when multiple antibiotics are used for serious infections. Approximately any antibiotic can cause antibiotic-associated colitis (also called pseudomembranous colitis, or Clostridium difficile colitis)., but the following have been involved in most cases: clindamycin, lincomycin, ampicillin, cephalosporins. The aminoglycosides (amikacin, gentamicin), erythromycin, trimethoprim-sulfamethoxazole, and fluoroquinolones (ciprofloxacin , levofloxacin) seem less likely to be the cause. Antibiotic associated diarrhea can occur within two days of completing a course of antibiotics or even up to six weeks later. The risk of antibiotic associated diarrhea rises with how often and how long the antibiotics are taken. Even the most gentle antibiotics, given for a short period of time, can occasionally lead to this problem. Therefore, if you have new symptoms of diarrhea, it is foremost that you make your doctor aware of any antibiotics you may have taken in the last any months. Yeast Overgrowth. One of the most coarse side effects of antibiotics is yeast overgrowth. Women who use antibiotics often produce bowel and vaginal yeast infections. Children treated repeatedly with antibiotics for ear infections often produce yeast and fungal infections of the middle ear. Antibiotics can, in some cases, hinder the immune response. For example, children given amoxicillin for continuing earaches suffer two to six times the rate of recurrent middle ear effusion than children who took a placebo. Agreeing to Carol Jessop, Md, Clinical Professor at the University of California at San Francisco, 80% of her patients who suffer from continuing fatigue syndrome (or continuing fatigue immunodeficiency syndrome) had a history of recurrent antibiotics treatment as a child, youthful or adult. Antibiotics will not cure viral illnesses, such as: Colds or flu Most coughs and bronchitis Sore throats not caused by strep Runny noses Stomach flu (viral gastroenteritis) Some ear infections When are antibiotics necessary? Here are a few examples: Ear infections - there are any types; many need antibiotics, but some do not. Sinus infections - most children with thick or green mucus do not have sinus infections. Antibiotics are needed for some long-lasting or severe cases. Strep throat - this health must be diagnosed by a laboratory test. Urinary tract infections Many wound and skin infections Sometimes it is very hard to tell when an illness is caused by a viral or bacterial infection. A test called a culture should be done to rule which bacteria, if any, are responsible for your illness. Without a culture, your health care supplier must pick an antibiotic based on an educated guess of what bacteria are most likely to be causing your illness. Sometimes, those educated guesses are wrong. Antibiotic resistance occurs when bacteria convert in a way that reduces or eliminates the effectiveness of antibiotics. These resistant bacteria survive and multiply - causing more harm, such as a longer illness, more doctor visits, and a need for more costly and toxic antibiotics. Some antibiotics become less efficient if they are taken with food. For example, azithromycin (zithromax) capsules should not be mixed with or taken with food, any way tablets may be taken without regard to food.

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20 Facts to Know About Antibiotics

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Tuesday, December 20, 2011

Antibiotics and Their Types, Uses and Side Effects

An antibiotic is a drug that kills or slows the growth of bacteria. Antibiotics are one class of antimicrobials, a larger group which also includes anti-viral, anti-fungal, and anti-parasitic drugs. Antibiotics are chemicals produced by or derived from microorganisms (i.e. bugs or germs such as bacteria and fungi). The first antibiotic was discovered by Alexander Fleming in 1928 in a significant breakthrough for medical science.

Antibiotics are among the most frequently prescribed medications in modern medicine.
Some antibiotics are 'bactericidal', meaning that they work by killing bacteria. Other antibiotics are 'bacteriostatic', meaning that they work by stopping bacteria multiplying.

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Each different type of antibiotic affects different bacteria in different ways. For example, an antibiotic might inhibit a bacterium's ability to turn glucose into energy, or its ability to construct its cell wall. When this happens, the bacterium dies instead of reproducing.

Some antibiotics can be used to treat a wide range of infections and are known as 'broad-spectrum' antibiotics. Others are only effective against a few types of bacteria and are called 'narrow-spectrum' antibiotics.

Side effects of antibiotics

Antibiotics can literally save lives and are effective in treating illnesses caused by bacterial infections. However, like all drugs, they have the potential to cause unwanted side effects. Many of these side effects are not dangerous, although they can make life miserable while the drug is being taken.

In general, antibiotics rarely cause serious side effects. The most common side effects from antibiotics are diarrhea, nausea, vomiting. Fungal infections of the mouth, digestive tract and vagina can also occur with antibiotics because they destroy the protective 'good' bacteria in the body (which help prevent overgrowth of any one organism), as well as the 'bad' ones, responsible for the infection being treated.

Some people are allergic to antibiotics, particularly penicillins. Allergic reactions cause swelling of the face, itching and a skin rash and, in severe cases, breathing difficulties. Allergic reactions require prompt treatment.

Types of antibiotics

There are many different kinds of antibiotics. The type of antibiotics you take depends on the type of infection you have and what kind of antibiotics are known to be effective.

The main classes of antibiotics:
Aminoglycosides Cephalosporins Fluoroquinolones Macrolides Penicillins Tetracyclines
Macrolides

There are a couple of new relatives of erythromycin (azithromycin and clarithromycin) that work the same way, but kill more bugs and have slightly fewer side effects. The erythromycin-like antibiotics are also known as macrolides. Macrolides belong to the polyketide class of natural products. Macrolide antibiotics are used to treat respiratory tract infections, genital, gastrointestinal tract, soft tissue infections caused by susceptible strains of specific bacteria.

Macrolides bind with ribosomes from susceptible bacteria to prevent protein production. This action is mainly bacteriostatic, but can also be bactericidal in high concentrations.

Macrolides cause very little allergy problems compared to the penicillins and cephalosporins, the biggest concern with these medicines is that they can irritate the stomach.

The most commonly-prescribed macrolides:
erythromycin clarithromycin azithromycin roxithromycin
Aminoglycosides

Aminoglycoside antibiotics are used to treat infections caused by gram-negative bacteria. Aminoglycosides may be used along with penicillins or cephalosporins to give a two-pronged attack on the bacteria. Aminoglycosides work quite well, but bacteria can become resistant to them. Since aminoglycosides are broken down easily in the stomach, they can't be given by mouth and must be injected. When injected, their side effects include possible damage to the ears and to the kidneys. This can be minimized by checking the amount of the drug in the blood and adjusting the dose so that there is enough drug to kill bacteria but not too much of it. Generally, aminoglycosides are given for short time periods.

The aminoglycosides are drugs which stop bacteria from making proteins. This effect is bactericidal.

The most commonly-prescribed aminoglycosides:
amikacin gentamicin kanamycin neomycin streptomycin tobramycin
Cephalosporins

Cephalosporins are grouped into "generations" by their antimicrobial properties. Cephalosporins are categorized chronically, and are therefore divided into first, second, and third generations. Currently, three generations of cephalosporins are recognized and a fourth has been proposed. Each newer generation of cephalosporins has greater gram negative antimicrobial properties than the preceding generation. The later-generation cephalosporins have greater effect against resistant bacteria.

Cephalosporins are used to treat pneumonia, strep throat, staph infections, tonsillitis, bronchitis, otitis media, various types of skin infections, gonorrhea. Cephalosporin antibiotics are also commonly used for surgical prophylaxis. Cephalosporins are closely related to the penicillins.

Cephalosporins have a bacteriocidal effect by inhibiting the synthesis of the bacteria cell wall.

Fluoroquinolones are known as broad-spectrum antibiotics, meaning they are effective against many bacteria. Fluoroquinolones are used to treat most common urinary tract infections, skin infections, and respiratory infections (such as sinusitis, pneumonia, bronchitis). Common side effects of fluoroquinolones include mainly the digestive system: mild stomach pain or upset, nausea, vomiting, and diarrhea. These are usually mild and go away over time. Fluoroquinolones should not be given during pregnancy.

Fluoroquinolones inhibit bacteria by interfering with their ability to make DNA. This activity makes it difficult for bacteria to multiply. This effect is bacteriocidal.

The most commonly-prescribed fluoroquinolones:
ciprofloxacin gatifloxacin gemifloxacin levofloxacin moxifloxacin norfloxacin ofloxacin trovafloxacin
Penicillins

Penicillin was the first antibiotic discovered by Alexander Fleming in 1929. Penicillins are used to treat skin infections, dental infections, ear infections, respiratory tract infections, urinary tract infections, gonorrhea. Penicillins are sometimes combined with other ingredients called beta-lactamase inhibitors, which protect the penicillin from bacterial enzymes that may destroy it before it can do its work.

Penicillins are usually very safe. The greatest risk is an allergic reaction, which can be severe. People who have been allergic to cephalosporins are likely to be allergic to penicillins.

Penicillins block the construction of bacteria cell walls, causing the walls to break down, and eventually killing the bacteria.

The most commonly-prescribed penicillins:
amoxicillin ampicillin bacampicillin oxacillin penicillin
Tetracyclines

Tetracyclines are a family of antibiotics used to treat a broad spectrum of bacterial infections. Tetracyclines were discovered in the late 1940s and were extremely popular when they were first discovered. The tetracycline antibiotics have a very broad spectrum of action.

Tetracyclines are used to treat mild acne, Rocky Mountain spotted fever, Lyme Disease, upper respiratory tract infections, urinary tract infections, sexually transmitted diseases, typhus.

The most commonly-prescribed tetracyclines:
tetracycline doxycycline minocycline
Antibiotic resistance

Antibiotics are extremely important in medicine, but unfortunately bacteria are capable of developing resistance to them. Antibiotic-resistant bacteria are germs that are not killed by commonly used antibiotics. When bacteria are exposed to the same antibiotics over and over, the bacteria can change and are no longer affected by the drug.

Bacteria have number of ways how they become antibiotic-resistant. For example, they possess an internal mechanism of changing their structure so the antibiotic no longer works, they develop ways to inactivate or neutralize the antibiotic. Also bacteria can transfer the genes coding for antibiotic resistance between them, making it possible for bacteria never exposed to an antibiotic to acquire resistance from those which have. The problem of antibiotic resistance is worsened when antibiotics are used to treat disorders in which they have no efficacy (e.g. antibiotics are not effective against infections caused by viruses), and when they are used widely as prophylaxis rather than treatment.

Resistance to antibiotics poses a serious and growing problem, because some infectious diseases are becoming more difficult to treat. Resistant bacteria do not respond to the antibiotics and continue to cause infection. Some of these resistant bacteria can be treated with more powerful medicines, but there some infections that are difficult to cure even with new or experimental drugs.

Antibiotics and Their Types, Uses and Side Effects

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